RT Journal Article
T1 A joint program of antimicrobial stewardship and hospital-acquired infection control to reduce healthcare-associated infections after kidney transplantation: The Hipomenes study
A1 Tiago Silva, José
A1 Pérez-Jacoiste Asín, María Asunción
A1 Fernández Ruiz, Mario
A1 González Monte, Esther
A1 Andrés Belmonte, Amado
A1 Aguado García, José María
A1 López Medrano, Francisco
AB Infection is a common complication in kidney transplant recipients (KTRs). The usefulness of antimicrobial stewardship programs (ASP) and hospital-acquired infection control (HAIC) initiatives in the general inpatient population is well established. We performed a quasi-experimental study to evaluate a joint ASP/HAIC initiative focused on KTRs. A dedicated ASP team optimized antimicrobial prescriptions in consecutive KTRs during the intervention period (June 2015-March 2016). A multifaceted, evidence-based HAIC program was concurrently implemented. Results were compared with the preceding period (June 2014-March 2015). We included 96 and 100 KTRs in the intervention and preintervention periods, respectively. There was a reduction in the consumption of meropenem (rate ratio [RR]: 0.63; 95% confidence interval [CI]: 0.53-0.75; P <.0001), ceftazidime (RR: 0.31; 95% CI: 0.21-0.45; P <.0001), vancomycin (RR: 0.65; 95% CI: 0.53-0.8; P <.0001), and ciprofloxacin (RR: 0.66; 95% CI: 0.55-0.81; P <.0001) and an increase of fosfomycin (RR: 1.80; 95% CI: 1.17-2.76; P =.008) during the intervention period. The incidence of cystitis (RR: 0.30; 95% CI: 0.28-0.33; P <.001) and upper urinary tract infection (RR: 0.56; 95% CI: 0.33-0.95; P =.04) decreased. A specific ASP/HAIC initiative was effective in optimizing antimicrobial use and reducing the incidence of common bacterial infections among KTRs.
PB Elsevier
SN 1600-6135
YR 2023
FD 2023-12-01
LK https://hdl.handle.net/20.500.14352/130788
UL https://hdl.handle.net/20.500.14352/130788
LA eng
NO Silva JT, Montoro J, Pérez-Jacoiste Asín MA, Fernández-Ruiz M, Polanco N, González E, et al. A joint program of antimicrobial stewardship and hospital-acquired infection control to reduce healthcare-associated infections after kidney transplantation: the Hipomenes study. Am J Transplant. 2023;23(12):1949-1960. doi:10.1016/j.ajt.2023.07.009.
NO Financiado con Fondos FEDER
NO European Commission
NO Instituto de Salud Carlos III (España)
DS Docta Complutense
RD 25 feb 2026