RT Journal Article
T1 OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives
A1 Sánchez-Puebla Fernández, Lidia
A1 López Cuenca, Inés
A1 García Martín, Elena Salobrar
A1 Fernández Albarral, José
A1 Matamoros Felipe, José Antonio
A1 Elvira Hurtado, Lorena
A1 Salazar Corral, Juan José
A1 Ramírez Sebastián, José Manuel
A1 Hoz Montañana, María Rosa De
A1 Ramírez Sebastián, Ana Isabel
AB The murine models of Alzheimer’s disease (AD) have advanced our understanding of the pathophysiology. In vivo studies of the retina using optical coherence tomography (OCT) have complemented histological methods; however, the lack of standardisation in OCT methodologies for murine models of AD has led to significant variations in the results of different studies. A literature search in PubMed and Scopus has been performed to review the different methods used in these models using OCT and to analyse the methodological characteristics of each study. In addition, some recommendations are offered to overcome the challenges of using OCT in murine models. The results reveal a lack of consensus on OCT device use, retinal area analysed, segmentation techniques, and analysis software. Although some studies use the same OCT device, variations in other parameters make the direct comparison of results difficult. Standardisation of retinal analysis criteria in murine models of AD using OCT is crucial to ensure consistent and comparable results. This implies the application of uniform measurement and segmentation protocols. Despite the absence of standardisation, OCT has proven valuable in advancing our understanding of the pathophysiology of AD.
PB MDPI
YR 2024
FD 2024-02-27
LK https://hdl.handle.net/20.500.14352/101985
UL https://hdl.handle.net/20.500.14352/101985
LA eng
NO Sánchez-Puebla, L.; López-Cuenca, I.; Salobrar-García, E.; Ramírez, A.I.; Fernández-Albarral, J.A.; Matamoros, J.A.; Elvira-Hurtado, L.; Salazar, J.J.; Ramírez, J.M.; de Hoz, R. OCT Imaging in Murine Models of Alzheimer’s Disease in a Systematic Review: Findings, Methodology and Future Perspectives. Biomedicines 2024, 12, 528. https://doi.org/10.3390/biomedicines12030528
NO Ministerio de Ciencia e Innovación de España
NO Universidad Complutense de Madrid (España)
DS Docta Complutense
RD 17 ago 2024