RT Journal Article
T1 Active Targeted Nanoformulations via Folate Receptors: State of the Art and Future Perspectives
A1 Martín Sabroso, Cristina
A1 Torres Suárez, Ana Isabel
A1 Alonso-González, Mario
A1 Fernández Carballido, Ana María
A1 Fraguas Sánchez, Ana Isabel
AB In normal tissues, the expression of folate receptors is low and limited to cells that are important for embryonic development or for folate reabsorption. However, in several pathological conditions some cells, such as cancer cells and activated macrophages, overexpress folate receptors (FRs). This overexpression makes them a potential therapeutic target in the treatment of cancer and inflammatory diseases to obtain a selective delivery of drugs at altered cells level, and thus to improve the therapeutic efficacy and decrease the systemic toxicity of the pharmacological treatments. Two strategies have been used to achieve this folate receptor targeting: (i) the use of ligands with high affinity to FRs (e.g., folic acid or anti-FRs monoclonal antibodies) linked to the therapeutic agents or (ii) the use of nanocarriers whose surface is decorated with these ligands and in which the drug is encapsulated. This manuscript analyzes the use of FRs as a target to develop new therapeutic tools in the treatment of cancer and inflammatory diseases with an emphasis on the nanoformulations that have been developed for both therapeutic and imaging purposes.
PB MPDI
SN 1999-4923
YR 2021
FD 2021-12-22
LK https://hdl.handle.net/20.500.14352/92361
UL https://hdl.handle.net/20.500.14352/92361
LA eng
NO Martín-Sabroso, C.; Torres-Suárez, A.I.; Alonso-González, M.; Fernández-Carballido, A.; Fraguas-Sánchez, A.I. Active Targeted Nanoformulations via Folate Receptors: State of the Art and Future Perspectives. Pharmaceutics 2022, 14, 14. https://doi.org/10.3390/pharmaceutics14010014
DS Docta Complutense
RD 8 abr 2025