RT Journal Article
T1 Heart Failure Is a Risk Factor for Suffering and Dying of Clostridium difficile Infection. Results of a 15-Year Nationwide Study in Spain
A1 Méndez Bailón, Manuel
A1 Jiménez García, Rodrigo
A1 Hernández Barrera, Valentín
A1 Miguel Díez, Javier De
A1 Miguel Yanes, José María De
A1 Muñoz Rivas, Nuria
A1 Lorenzo Villalba, Noel
A1 Carabantes Alarcón, David
A1 Zamorano León, José Javier
A1 Astasio Arbiza, Paloma
A1 Ortega Molina, Soledad Paloma
A1 López De Andrés, Ana Isabel
AB Background: We aimed to (1) analyze time trends in the incidence and in-hospital outcomes of heart failure (HF) patients suffering Clostridioides difficile infection (CDI); (2) compare clinical characteristics of CDI patients between those with HF and matched non-HF patients; and (3) identify predictors of in-hospital mortality (IHM) among HF patients suffering CDI. Methods: Retrospective study using the Spanish National Hospital Discharge Database from 2001 to 2015. Patients of age ≥40 years with CDI were included. For each HF patient, we selected a year, age, sex, and readmission status-matched non-HF patient. Results: We found 44,695 patients hospitalized with CDI (15.46% with HF). HF patients had a higher incidence of CDI (202.05 vs. 145.09 per 100,000 hospitalizations) than patients without HF (adjusted IRR 1.35; 95% CI 1.31–1.40). IHM was significantly higher in patients with HF when CDI was coded as primary (18.39% vs. 7.63%; p < 0.001) and secondary diagnosis (21.12% vs. 14.76%; p < 0.001). Among HF patient’s predictor of IHM were older age (OR 8.80; 95% CI 2.55–20.33 for ≥85 years old), those with more comorbidities (OR 1.68; 95% CI 1.12–2.53 for those with Charlson Comorbidity index ≥2), and in those with severe CDI (OR 6.19; 95% CI 3.80–10.02). Conclusions: This research showed that incidence of CDI was higher in HF than non-HF patients. HF is a risk factor for IHM after suffering CDI.
PB MDPI
SN 2077-0383
YR 2020
FD 2020-02-25
LK https://hdl.handle.net/20.500.14352/8200
UL https://hdl.handle.net/20.500.14352/8200
LA eng
NO Méndez Bailón, M., Jiménez García, R., Hernández Barrera, V. et al. «Heart Failure Is a Risk Factor for Suffering and Dying of Clostridium Difficile Infection. Results of a 15-Year Nationwide Study in Spain». Journal of Clinical Medicine, vol. 9, n.o 3, febrero de 2020, p. 614. DOI.org (Crossref), https://doi.org/10.3390/jcm9030614.
DS Docta Complutense
RD 10 abr 2025