RT Journal Article
T1 Lymphoproliferation Impairment and Oxidative Stress in Blood Cells from Early Parkinson’s Disease Patients
A1 Vida, Carmen
A1 Kobayashi, Hikaru
A1 Garrido, Antonio
A1 Martínez de Toda, Irene
A1 Carro, Eva
A1 Molina, José
A1 Fuente del Rey, Mónica de la
AB In Parkinson’s Disease (PD), the peripheral changes in the functional capacity and redox state of immune cells has been scarcely investigated, especially in the early PD stages. Aging is a risk factor for PD, and the age-related impairment of the immune system, based on a chronic-oxidative stress situation, is involved in the rate of aging. We analyzed several functions in isolated peripheral blood neutrophils and mononuclear cells from PD stage 2 patients, and compared the results to those in healthy elderly and adult controls. Several oxidative stress and damage parameters were studied in whole blood cells. The results showed an impairment of the lymphoproliferative response in stimulated conditions in the PD patients compared with age-matched controls, who also showed typical immunosenescence in comparison with adult individuals. Higher oxidative stress and damage were observed in whole blood cells from PD patients (lower glutathione peroxidase activity, and higher oxidized glutathione and malondialdehyde contents). Our results suggest an accelerated immunosenescence in PD stage 2, and that several of the parameters studied could be appropriate peripheral biomarkers in the early stages of PD.
PB MDPI
SN 1422-0067
YR 2019
FD 2019-02-12
LK https://hdl.handle.net/20.500.14352/12491
UL https://hdl.handle.net/20.500.14352/12491
LA eng
NO Instituto de Salud Carlos III (ISCIII)/ FEDER
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 8 may 2024