RT Journal Article
T1 Apolipoprotein E ɛ4–related effects on cognition are limited to the Alzheimer’s disease spectrum
A1 Fernández Lucas, Alberto Amable
A1 Vaquero Zamora, Lucía
A1 Bajo Bretón, Ricardo
A1 Zuluaga Arias, María del Pilar
AB Whether the deleterious efects of APOE4 are restricted to the Alzheimer’s disease (AD) spectrum or cause cognitive impairment irrespectively of the development of AD is still a matter of debate, and the focus of this study. Our analyses included APOE4 genotype, neuropsychological variables, amyloid-βeta (Aβ) and Tau markers, FDG-PET values, and hippocampal volumetry data derived from the healthy controls sample of the ADNI database. We formed 4 groups of equal size (n=30) based on APOE4 carriage and amyloid-PET status. Baseline and followup (i.e., 48  months post-baseline) results indicated that Aβ-positivity was the most important factor to explain poorer cognitive performance, while APOE4 only exerted a signifcant efect in Aβ-positive subjects. Additionally, multiple regression analyses evidenced that, within the Aβ-positive sample, hippocampal volumetry explained most of the variability in cognitive performance for APOE4 carriers. These fndings represent a strong support for the so-called preclinical/prodromal hypothesis, which states that the reported diferences in cognitive performance between healthy carriers and non-carriers are mainly due to the APOE4’s capability to increase the risk of AD. Moreover, our results reinforce the notion that a synergistic interaction of Aβ and APOE4 elicits a neurodegenerative process in the hippocampus that might be the main cause of impaired cognitive performance.
PB Springer Nature
SN 2509-2715
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/71324
UL https://hdl.handle.net/20.500.14352/71324
LA eng
NO Fernández Lucas, A. A., Vaquero Zamora, L., Bajo Bretón, R. et al. «Apolipoprotein E Ɛ4–Related Effects on Cognition Are Limited to the Alzheimer’s Disease Spectrum». GeroScience, vol. 44, n.o 1, febrero de 2022, pp. 195-209. DOI.org (Crossref), https://doi.org/10.1007/s11357-021-00450-x.
NO CRUE-CSIC (Acuerdos Transformativos 2021)
DS Docta Complutense
RD 6 abr 2025