RT Journal Article
T1 Targeting of key pathogenic factors from gram-positive bacteria by the soluble ectodomain of the scavenger-like lymphocyte receptor CD6
A1 Martínez-Florensa, Mario
A1 Consuegra-Fernández, Marta
A1 Martínez, Vanessa
A1 Cañadas Benito, Olga
A1 Armiger-Borràs, Noelia
A1 Bonet-Roselló, Lizette
A1 Farrán, Aina
A1 Vila, Jordi
A1 Casals Carro, María Cristina
A1 Lozano, Francisco
AB Gram-positive bacteria cause a broad spectrum of infection-related diseases in both immunocompetent and immunocompromised hosts, ranging from localized infections to severe systemic conditions such as septic and toxic shock syndromes. This situation has been aggravated by the recent emergence of multidrug-resistant strains, thus stressing the need for alternative therapeutic approaches. One such possibility would be modulating the host's immune response. Herein, the potential use of a soluble form of the scavenger-like human lymphocyte receptor CD6 (shCD6) belonging to an ancient family of innate immune receptors has been evaluated. shCD6 can bind to a broad spectrum of gram-positive bacteria thanks to the recognition of highly conserved cell wall components (lipoteichoic acid [LTA] and peptidoglycan [PGN]), which are essential for their viability and pathogenicity and are not amenable to antibiotic resistance. shCD6 has in vitro inhibitory effects on both bacterial growth and Toll-like receptor-mediated inflammatory response induced by LTA plus PGN. In vivo infusion of shCD6 improves survival on mouse models of septic shock by Staphylococcus aureus (either multidrug-resistant or -sensitive) or their endotoxins (LTA + PGN) or exotoxins (TSST-1). These results support the use of shCD6 and/or other scavenger-like immune receptors in the treatment of severe gram-positive-induced infectious conditions.
PB Oxford University Press
SN 0022-1899
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/99631
UL https://hdl.handle.net/20.500.14352/99631
LA eng
NO Martínez-Florensa M, Consuegra-Fernández M, Martínez VG, Cañadas O, Armiger-Borràs N, Bonet-Roselló L, Farrán A, Vila J, Casals C, Lozano F. Targeting of key pathogenic factors from gram-positive bacteria by the soluble ectodomain of the scavenger-like lymphocyte receptor CD6. J. Infect. Dis. 2014 Apr 1;209(7):1077-86.
NO Ministerio de Economía y Competitividad (España)
NO Generalitat de Catalunya
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 8 abr 2025