RT Journal Article
T1 Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer
A1 Corchado Cobos, Roberto
A1 García Sancha, Natalia
A1 Mendiburu-Eliçabe Garganta, Marina
A1 Gómez Vecino, Aurora
A1 Jiménez Navas, Alejandro
A1 Pérez Baena, Manuel Jesús
A1 Holgado Madruga, Marina
A1 Mao, Jian Hua
A1 Cañueto Álvarez, Javier
A1 Castillo Lluva, Sonia
A1 Pérez Losada, Jesús
AB Metabolic changes that facilitate tumor growth are one of the hallmarks of cancer. The triggers of these metabolic changes are located in the tumor parenchymal cells, where oncogenic mutations induce an imperative need to proliferate and cause tumor initiation and progression. Cancer cells undergo significant metabolic reorganization during disease progression that is tailored to their energy demands and fluctuating environmental conditions. Oxidative stress plays an essential role as a trigger under such conditions. These metabolic changes are the consequence of the interaction between tumor cells and stromal myofibroblasts. The metabolic changes in tumor cells include protein anabolism and the synthesis of cell membranes and nucleic acids, which all facilitate cell proliferation. They are linked to catabolism and autophagy in stromal myofibroblasts, causing the release of nutrients for the cells of the tumor parenchyma. Metabolic changes lead to an interstitium deficient in nutrients, such as glucose and amino acids, and acidification by lactic acid. Together with hypoxia, they produce functional changes in other cells of the tumor stroma, such as many immune subpopulations and endothelial cells, which lead to tumor growth. Thus, immune cells favor tissue growth through changes in immunosuppression. This review considers some of the metabolic changes described in breast cancer.
PB MPDI
SN 2072-6694
YR 2022
FD 2022-01-10
LK https://hdl.handle.net/20.500.14352/72070
UL https://hdl.handle.net/20.500.14352/72070
LA eng
NO Corchado-Cobos R, García-Sancha N, Mendiburu-Eliçabe M, Gómez-Vecino A, Jiménez-Navas A, Pérez-Baena MJ, et al. Pathophysiological Integration of Metabolic Reprogramming in Breast Cancer. Cancers 2022;14:322. https://doi.org/10.3390/cancers14020322.
NO Ministerio de Ciencia e Innovación (España)
NO Instituto de Salud Carlos III
NO Junta de Castilla y León
NO Federación Española de Enfermedades Raras
DS Docta Complutense
RD 11 may 2025