RT Journal Article
T1 Efficacy of adjunctive therapies in patients with gingival inflammation: a systematic review and meta‐analysis
A1 Figuero Ruiz, Elena
A1 Roldán, Silvia
A1 Serrano, Jorge
A1 Escribano, Marta
A1 Martín Álvaro, María Concepción
A1 Preshaw, Philip
AB Aim:To evaluate the efficacy of adjunctive therapies in reducing gingivitis and plaque by means of a systematic review of randomized clinical trials (RCTs).Material and Methods:A search protocol was designed to identify 6‐month RCTs that investigated the efficacy of adjuncts to mechanical plaque control on gingivitis and plaque. Following screening, relevant information was extracted, and quality and potential risk of bias were estimated. Mean treatment differences were calculated to obtain standardized mean differences and weighted mean differences (SMD and WMD) as appropriate.Results:Meta‐analyses included 70 studies of adjunctive antiseptics. Compared with mechanical plaque control alone, adjuncts yielded statistically significant reductions in gingival index (n = 72; SMD = −1.268; 95% CI [−1.489; −1.047]; p < .001; I2 = 96.2%), bleeding (%) (n = 26, WMD=−14.62%; 95% CI [−18.01%; −11.23%]; p < .001; I2 = 95.1%), plaque index (n = 93, SMD = −1.017; 95% CI [−1.194; −0.840]; p < .001; I2 = 95.3%) and plaque (%) (n = 23; WMD = −18.20%; 95% CI [−24.00%; −12.50%]; p < .001; I2 = 96.9%). Mouthrinses resulted in greater reductions in per cent plaque compared with dentifrices (meta‐regression, coefficient = 13.80%; 95% CI [2.40%; 25.10%]; p = .020). The antiseptic agents were similarly effective in reducing gingivitis and plaque in patients with dental plaque‐induced gingivitis (intact periodontium) or previously treated periodontitis with gingival inflammation.Conclusion:Adjunctive antiseptics in mouthrinses and dentifrices provide statistically significant reductions in gingival, bleeding and plaque indices.
PB Wiley
SN 0303-6979
SN 1600-051X
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/112036
UL https://hdl.handle.net/20.500.14352/112036
LA eng
NO Figuero E, Roldán S, Serrano J, Escribano M, Martín C, Preshaw PM. Efficacy of adjunctive therapies in patients with gingival inflammation: A systematic review and meta-analysis. J Clin Periodontol. 2020 Jul;47 Suppl 22:125-143. doi: 10.1111/jcpe.13244
NO Grupo de Investigación ETEP (Etiología y Terapia de las Enfermedades Periodontales), Universidad Complutense, Madrid, España
DS Docta Complutense
RD 26 abr 2025