RT Journal Article
T1 Supercritical fluid impregnation of naproxen into mesoporous SiO2 SBA-15
A1 González, Juan
A1 Pérez Velilla, Eduardo
A1 Pepczynska, Marzena
A1 Calvo Garrido, María Lourdes
A1 Cabañas Poveda, Albertina
AB Naproxen was impregnated into mesoporous SiO2 SBA-15 using the Supercritical Solution Impregnation (SSI) technique. Experiments were performed at 50–70ºC and 15–25 MPa in pure CO2 and CO2 modified with ethanol, ethyl acetate and menthol. Materials were also impregnated from liquid solutions in ethanol and chloroform. In the SSI experiments, naproxen was deposited on the internal surface of the mesopores as shown by N2-adsorption experiments. The percentage of naproxen impregnated decreased from 11.1% to 7.4% mass as the CO2 density increased. Likewise, adding ethanol, ethyl acetate or menthol to CO2 decreased the percentage of naproxen adsorbed on the support. Thermal analysis showed that naproxen impregnated on SiO2 by SSI became amorphous. FTIR and XRD confirmed the loss of crystallinity of naproxen and its interaction with the SiO2 support. Samples impregnated in liquid medium however kept partially their crystallinity. Release tests of naproxen on SiO2 SBA-15 prepared by SSI followed an almost zero-order release profile; the drug is released at a constant rate into a PBS pH= 7.4 medium. The release rate slowed down in comparison to that of pure naproxen, due to the interaction of the drug with the support and the diffusion of the drug outside the support mesopores. Thus, a sustained release system was achieved, which may help to attain a longer therapeutic effect with a lower naproxen dose.
PB Elsevier
SN 2212-9839
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/92071
UL https://hdl.handle.net/20.500.14352/92071
LA eng
NO Juan González, Eduardo Pérez, Marzena Pepczynska, Lourdes Calvo, Albertina Cabañas, Supercritical Solution Impregnation of naproxen into mesoporous SiO2 SBA-15, Journal of CO2 Utilization, Volume 73, 2023, 102518. https://doi.org/10.1016/j.jcou.2023.102518.
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 4 jun 2025