RT Journal Article
T1 Translating eco-evolutionary biology into therapy to tackle antibiotic resistance
A1 Sanz García, Fernando
A1 Gil Gil, Teresa
A1 Laborda, Pablo
A1 Blanco Torres, Paula
A1 Ochoa Sánchez, Luz Edith
A1 Baquero, Fernando
A1 Martínez, José Luis
A1 Hernando-Amado, Sara
AB Antibiotic resistance is currently one of the most important public health problems. The golden age of antibiotic discovery ended decades ago, and new approaches are urgently needed. Therefore, preserving the efficacy of the antibiotics currently in use and developing compounds and strategies that specifically target antibiotic-resistant pathogens is critical. The identification of robust trends of antibiotic resistance evolution and of its associated trade-offs, such as collateral sensitivity or fitness costs, is invaluable for the design of rational evolution-based, ecology-based treatment approaches. In this Review, we discuss these evolutionary trade-offs and how such knowledge can aid in informing combination or alternating antibiotic therapies against bacterial infections. In addition, we discuss how targeting bacterial metabolism can enhance drug activity and impair antibiotic resistance evolution. Finally, we explore how an improved understanding of the original physiological function of antibiotic resistance determinants, which have evolved to reach clinical resistance after a process of historical contingency, may help to tackle antibiotic resistance.
PB Nature
SN 1740-1526
SN 1740-1534
YR 2023
FD 2023-05-19
LK https://hdl.handle.net/20.500.14352/107445
UL https://hdl.handle.net/20.500.14352/107445
LA eng
NO Sanz-García, F., Gil-Gil, T., Laborda, P. et al. Translating eco-evolutionary biology into therapy to tackle antibiotic resistance. Nat Rev Microbiol 21, 671–685 (2023). https://doi.org/10.1038/s41579-023-00902-5
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 8 abr 2025