RT Journal Article
T1 Autophagy in major human diseases
A1 Klionsky, Daniel J.
A1 Bravo San Pedro, José Manuel
A1 Pietrocola, Federico
AB Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
PB Springer
SN 0261-4189
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/128916
UL https://hdl.handle.net/20.500.14352/128916
LA eng
NO Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, et al. Autophagy in major human diseases. EMBO journal. 2021;40(19):e108863
DS Docta Complutense
RD 20 mar 2026