RT Journal Article
T1 Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System
A1 Gómez Pinedo, Ulises
A1 García Ávila, Yolanda
A1 Gallego Villarejo, Lucía
A1 Matías-Guiu Guia, Jordi A.
A1 Benito Martín, María Soledad
A1 Esteban García, Noelia
A1 Sanclemente Alamán, Inmaculada
A1 Pytel, Vanesa
A1 Moreno Jiménez, Lidia
A1 Sancho Bielsa, Francisco
A1 Vidorreta Ballesteros, Lucía
A1 Montero Escribano, Paloma
A1 Matías-Guiu Guía, Jorge
AB Introduction: AQP4 (aquaporin-4)–immunoglobulin G (IgG)-mediated neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory demyelinating disease that affects the central nervous system, particularly the spinal cord and optic nerve; remyelination capacity in neuromyelitis optica is yet to be determined, as is the role of AQP4–IgG in cell differentiation. Material and Methods: We included three groups—a group of patients with AQP4–IgG-positive neuromyelitis optica, a healthy group, and a sham group. We analyzed differentiation capacity in cultures of neurospheres from the subventricular zone of mice by adding serum at two different times: early and advanced stages of differentiation. We also analyzed differentiation into different cell lines. Results and Conclusions: The effect of sera from patients with NMOSD on precursor cells differs according to the degree of differentiation, and probably affects oligodendrocyte progenitor cells from NG2 cells to a lesser extent than cells from the subventricular zone; however, the resulting oligodendrocytes may be compromised in terms of maturation and possibly limited in their ability to generate myelin. Furthermore, these cells decrease in number with age. It is very unlikely that the use of drugs favoring the migration and differentiation of oligodendrocyte progenitor cells in multiple sclerosis would be effective in the context of neuromyelitis optica, but cell therapy with oligodendrocyte progenitor cells seems to be a potential alternative.
PB MPDI
SN 1422-0067
YR 2021
FD 2021-05-14
LK https://hdl.handle.net/20.500.14352/7051
UL https://hdl.handle.net/20.500.14352/7051
LA eng
NO Gómez Pinedo, U., García Ávila, Y., Gallego Villarejo, L. et al. «Sera from Patients with NMOSD Reduce the Differentiation Capacity of Precursor Cells in the Central Nervous System». International Journal of Molecular Sciences, vol. 22, n.o 10, mayo de 2021, p. 5192. DOI.org (Crossref), https://doi.org/10.3390/ijms22105192.
DS Docta Complutense
RD 7 abr 2025