RT Journal Article
T1 Redox-Responsive Mesoporous Silica Nanoparticles for Cancer Treatment: Recent Updates
A1 Gisbert Garzarán, Miguel
A1 Vallet Regí, María Dulce Nombre
AB Mesoporous silica nanoparticles have been widely applied as carriers for cancer treatment. Among the different types of stimuli-responsive drug delivery systems, those sensitive to redox stimuli have attracted much attention. Their relevance arises from the high concentration of reduc-tive species that are found within the cells, compared to bloodstream, which leads to the drug re-lease taking place only inside cells. This review is intended to provide a comprehensive overview of the most recent trends in the design of redox-responsive mesoporous silica nanoparticles. First, a general description of the biological rationale of this stimulus is presented. Then, the different types of gatekeepers that are able to open the pore entrances only upon application of reductive conditions will be introduced. In this sense, we will distinguish among those targeted and those non-targeted toward cancer cells. Finally, a new family of bridged silica nanoparticles able to degrade their struc-ture upon application of this type of stimulus will be presented.
PB MDPI
SN 2079-4991
YR 2021
FD 2021-08-28
LK https://hdl.handle.net/20.500.14352/4414
UL https://hdl.handle.net/20.500.14352/4414
LA eng
NO RESEARCH ID   S-2443-2016  (Miguel Gisbert Garzarán)ORCID 0000-0001-9815-0354 (Miguel Gisbert Garzarán)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. Horizonte 2020
DS Docta Complutense
RD 18 dic 2025