RT Journal Article
T1 In-silico modeling of early-stage biofilm formation
A1 Nie, Pin
A1 Alarcón, Francisco
A1 López-Montero, Iván
A1 Orgaz Martín, Belén
A1 Valeriani, Chantal
A1 Pica Ciamarra, Massimo
AB Bacteria can form biofilms in different environmental conditions, e.g. pH, temperature, nutrients, etc. Biofilm growth, therefore, is an extremely robust process. Because of this, while biofilm growth is a complex process affected by several variables, insights into biofilm formation could be obtained by studying simple schematic models. In this manuscript, we describe a hybrid molecular dynamics and Monte Carlo model for the simulation of the early stage formation of a biofilm, to explicitly demonstrate that it is possible to account for most of the processes expected to be relevant. The simulations account for the growth and reproduction of the bacteria, for their interaction and motility, for the synthesis of extracellular polymeric substances and exopolisaccharide trails. We describe the effect of these processes on the early stage formation of biofilms, in two dimensions, and also discuss preliminary three-dimensional results.
PB Taylor & Francis Inc
SN 1539-445X
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/8302
UL https://hdl.handle.net/20.500.14352/8302
LA eng
NO This work was supported by the Ministry of Education Singapore [2019-T1-001-03].
NO Ministry of Education, Singapore
DS Docta Complutense
RD 6 abr 2025