RT Journal Article
T1 Transcriptome Analysis Identifies Novel Mechanisms Associated with the Antitumor Effect of Chitosan‐StabilizedSelenium Nanoparticles.
A1 Estévez Sánchez, Héctor
A1 García Calvo, Estefanía
A1 Rivera-Torres, José
A1 Vallet Regí, María Dulce Nombre
A1 González Ortiz, Blanca
A1 Luque García, José Luis
AB Selenium nanoparticles (SeNPs) have been receiving special attention in recent years due to their antioxidant capacity and antitumor properties. However, the mechanisms associated with these properties remain to be elucidated. For this reason, a global transcriptome analysis has been designed in this work and it was carried out using human hepatocarcinoma cells and chitosan‐ stabilized SeNPs (Ch‐SeNPs) to identify new targets and pathways related to the antitumor mechanisms associated with Ch‐SeNPs. The results obtained confirm the alteration of the cell cycle and the effect of Ch‐SeNPs on different tumor suppressors and other molecules involved in key mechanisms related to cancer progression. Furthermore, we demonstrated the antioxidant properties of these nanoparticles and their capacity to induce senescence, which was further confirmed through the measurement of β‐galactosidase activity.
PB MDPI
SN 1999-4923
YR 2021
FD 2021-03-08
LK https://hdl.handle.net/20.500.14352/8011
UL https://hdl.handle.net/20.500.14352/8011
LA eng
NO RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)RESEARCHER ID K-4773-2015 (Blanca González Ortiz)ORCID 0000-0002-0493-6071 (Blanca González Ortiz)
NO Unión Europea. Horizonte 2020
NO Ministerio de Ciencia e Innovación (MICINN)
DS Docta Complutense
RD 12 abr 2025