RT Journal Article
T1 Allergy to pumpkin and cross-reactivity to other Cucurbitaceae fruits
A1 Figueredo, Elena
A1 Cuesta-Herranz, Javier
A1 Minguez, Ascensión
A1 Vidarte, Luis
A1 Pastor Vargas, Carlos
A1 Heras González, Manuel De Las
A1 Vivanco Martínez, Fernando
A1 Lahoz, Carlos
AB Most human nephritis is due to glomerular deposition and/or formation of immune complexes (IC). In cultured mesangial cells, Fc receptor stimulation induces proliferation, matrix synthesis, and release of several mediators implicated in the initiation and progression of glomerular injury. Since Ig Fc fragments in vitro modified these phenomena, we studied the effects of systemic administration of IgG Fc fragments on the evolution of experimental IC nephritis. Fc fragment injection (1 mg/day i.p.) to rats with ongoing nephritis (proteinuria 20–50 mg/24 h vs 9 6 0.2 mg/24 h in controls) markedly ameliorates proteinuria, renal function, and morphological renal lesions. This was accompanied by a reduction in the renal synthesis of chemokines (monocyte chemoattractant protein-1, IFN-inducible protein-10, and cytokine-induced neutrophil chemoattractant-1), matrix proteins, and growth factors (platelet-derived growth factor, and TGF-b), and in the activity of transcription factors. The treatment did not affect the glomerular deposition of IgG IC and complement C1q. In contrast, a decrease in the renal expression and production of C3 was observed without changes in serum complement levels. In vitro, very low complement consumption and no C3b covalent interaction were observed with Fc fragments, confirming that they did not modify systemic complement activity. These results indicate that the administration of Fc fragments prevents the development of glomerular damage in an aggressive model of proliferative glomerulonephritis through mechanisms involving a reduced local generation of complement, chemokines and growth factors. Modulation of IC-mesangial cell interaction by Fc fragment administration could represent a new approach to the treatment of severe immune nephritis
PB Elsevier
SN 0091-6749
YR 2000
FD 2000
LK https://hdl.handle.net/20.500.14352/93011
UL https://hdl.handle.net/20.500.14352/93011
LA eng
NO Figueredo E, Cuesta-Herranz J, Minguez A, Vidarte L, Pastor C, De Las Heras M, Vivanco F, Lahoz C. Allergy to pumpkin and cross-reactivity to other Cucurbitaceae fruits. J Allergy Clin Immunol. 2000 Aug;106(2):402-3. doi: 10.1067/mai.2000.108109. PMID: 10932088.
DS Docta Complutense
RD 19 jun 2025