RT Journal Article
T1 pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery
A1 Gisbert Garzarán, Miguel
A1 Manzano García, Miguel
A1 Vallet Regí, María Dulce Nombre
AB The application of nanotechnology to medicine constitutes a major field of research nowadays. In particular, the use of mesoporous silica and carbon nanoparticles has attracted the attention of numerous researchers due to their unique properties, especially when applied to cancer treatment. Many strategies based on stimuli-responsive nanocarriers have been developed to control the drug release and avoid premature release. Here, we focus on the use of the subtle changes of pH between healthy and diseased areas along the body to trigger the release of the cargo. In this review, different approximations of pH-responsive systems are considered: those based on the use of the host-guest interactions between the nanocarriers and the drugs, those based on the hydrolysis of acid-labile bonds and those based on supramolecular structures acting as pore capping agents.
PB MDPI (Multidisciplinary Digital Publishing Institute)
SN 2306-5354
YR 2017
FD 2017-01-18
LK https://hdl.handle.net/20.500.14352/17593
UL https://hdl.handle.net/20.500.14352/17593
LA spa
NO RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)RESEARCHER ID K-3719-2014 (Miguel Manzano García)RESEARCHER ID M-3378-2014 (Miguel Manzano García)			ORCID 0000-0001-6238-6111 (Miguel Manzano García)RESEARCHER ID S-2443-2016 (Miguel Gisbert Garzarán)ORCID 0000-0001-9815-0354 (Miguel Gisbert Garzarán)
NO Unión Europea. H2020
NO European Research Council
DS Docta Complutense
RD 15 jun 2025