RT Journal Article
T1 Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption
A1 Sola Vendrell, Emma
A1 Moyano-Cires Ivanoff, Paula Viviana
A1 Flores A, 
A1 García Lobo, Jimena
A1 García Sánchez, José Manuel
A1 Frejo Moya, María Teresa
A1 Anadón Baselga, María José
A1 Pelayo Alarcón, Adela
A1 Fernández Fernández, María De La Cabeza
A1 Del Pino J, 
A1 Pino Sans, Javier Del
AB Cadmium (Cd) single and repeated exposure produces cognitive dysfunctions. Basal forebrain cholinergic neu rons (BFCN) regulate cognitive functions. BFCN loss or cholinergic neurotransmission dysfunction leads to cognitive disabilities. Thyroid hormones (THs) maintain BFCN viability and functions, and Cd disrupts their levels. However, Cd-induced BFCN damages and THs disruption involvement was not studied. To research this we treated male Wistar rats intraperitoneally with Cd once (1 mg/kg) or repetitively for 28 days (0.1 mg/kg) with/without triiodothyronine (T3, 40 µg/kg/day). Cd increased thyroid-stimulating-hormone (TSH) and decreased T3 and tetraiodothyronine (T4). Cd altered cholinergic transmission and induced a more pronounced neurodegeneration on BFCN, mediated partially by THs reduction. Additionally, Cd antagonized muscarinic 1 receptor (M1R), overexpressed acetylcholinesterase S variant (AChE-S), downregulated AChE-R, M2R, M3R and M4R, and reduced AChE and choline acetyltransferase activities through THs disruption. These results may assist to discover cadmium mechanisms that induce cognitive disabilities, revealing a new possible therapeutic tool.
PB Elsevier
SN 1382-6689
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/115572
UL https://hdl.handle.net/20.500.14352/115572
LA eng
NO Sola, E., Moyano, P., Flores, A., García, J., García, J. M., Anadon, M. J., Frejo, M. T., Pelayo, A., de la Cabeza Fernandez, M., & del Pino, J. (2022). Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption. Environmental Toxicology and Pharmacology, 90. https://doi.org/10.1016/J.ETAP.2021.103791
NO Emma Sola: Methodology, Investigation, Writing – original draft, Writing – review & editing. Paula Moyano: Methodology, Investiga tion, Writing – original draft, Writing – review & editing. Andrea Flores: Methodology, Investigation, Writing – original draft, Writing – review & editing. Jimena García: Investigation, Writing – original draft, Writing – review & editing. Jose ´ Manuel García: Methodology, Investigation, Validation, Writing- Reviewing and Editing. Maria Jose Anadon: Methodology, Data curation, Writing – review & editing. María Teresa Frejo: Formal analysis, Writing – review & editing. Adela Pelayo: Resources, Formal analysis, Data curation, Supervision. Maria de la Cabeza Fernandez: Investigation, Writing – review & editing. Javier Del Pino: Conceptualization, Methodology, Project administra tion, Supervision, Writing – review & editing.
NO Universidad Complutense de Madrid
NO Banco Santander
DS Docta Complutense
RD 18 abr 2025