RT Journal Article
T1 Progressive uterine artery occlusion in the Guinea pig leads to defects in placental structure that relate to fetal growth
A1 Lopez-Tello, Jorge
A1 Jiménez Martínez, María de los Ángeles
A1 Herrera, Emilio
A1 Krause, Bernardo
A1 Sferruzzi-Perri, Amanda
AB Intrauterine growth restriction (IUGR) is a common obstetric complication with immediate and life-long consequences for offspring health. Yet the mechanisms underlying its aetiology require elucidation. Recent work in the guinea pig shows that progressive uterine artery occlusion induced IUGR and vascular dysfunction in pups. Here we explore the extent to which uterine artery occlusion influences fetal outcomes via impacts on placental morphology. Our study demonstrates that uterine artery occlusion severely compromised both the labyrinth exchange zone (increased fibrosis and reduced vascularisation, trophoblast volume, surface area and diffusing capacity) and interlobium zone (increased apoptosis), which likely contributed to the IUGR observed.
PB Elsevier
SN 0143-4004
YR 2018
FD 2018
LK https://hdl.handle.net/20.500.14352/95693
UL https://hdl.handle.net/20.500.14352/95693
LA eng
NO Supplementary data to this article can be found online at https://doi.org/10.1016/j.placenta.2018.10.003.
NO Royal Society
NO Fondo Nacional de Desarrollo Científico y Tecnológico (Chile)
DS Docta Complutense
RD 17 abr 2025