RT Journal Article
T1 Transition from mild cognitive impairment to normal cognition: Determining the predictors of reversion with multi‐state Markov models
A1 Sanz Blasco, Rubén
A1 Ruiz Sánchez de León, José María
A1 Ávila‐Villanueva, Marina
A1 Valentí‐Soler, Meritxel
A1 Gómez‐Ramírez, Jaime
A1 Fernández Blázquez, Miguel Ángel
AB Introduction. The theoretical framework of the Alzheimer's disease continuum considers transition between stages in a unidirectional manner. Here we examine the rate of reversion from mild cognitive impairment (MCI) to normal cognition (NC) and explore a set of potential variables associated with this phenomenon. Methods. A total of 985 Spanish community‐dwelling individuals aged 70 years and over at baseline were monitored for 5 years. During this time, 173 MCI and 36 dementia cases were identified. Multi‐state Markov models were performed to characterize transitions between states through the dementia continuum. Results. The rate of reversion from MCI to NC was 11%. There were significant non‐modifiable (age, socioeconomic status, or apolipoprotein E) and modifiable factors (cognitive training or absence of affective symptoms) associated with reversion. Discussion. Overall, our results highlight that the likelihood of progression from MCI to dementia is very similar to that of reversion from MCI to NC.
PB Alzheimer's Association / Wiley
SN 1552-5260
SN 1552-5279
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/102995
UL https://hdl.handle.net/20.500.14352/102995
LA eng
DS Docta Complutense
RD 4 abr 2025