RT Journal Article
T1 Insights into the evolution of the prdm1/Blimp1 gene family in teleost fish
A1 Perdiguero Jiménez, Pedro
A1 Goméz-Esparza, Maria
A1 Martín, Diana
A1 Bird, Steve
A1 Soleto, Irene
A1 Morel, Esther
A1 Díaz-Rosales, Patricia
A1 Tafalla, Carolina
AB In mammals, Blimp1 (B lymphocyte-induced maturation protein 1) encoded by the prdm1 gene and its homolog Hobit (homolog of Blimp1 in T cells) encoded by znf683, represent key transcriptional factors that control the development and differentiation of both B and T cells. Despite their essential role in the regulation of acquired immunity, this gene family has been largely unexplored in teleosts to date. Until now, one prdm1 gene has been identified in most teleost species, whereas a znf683 homolog has not yet been reported in any of these species. Focusing our analysis on rainbow trout (Oncorhynchus mykiss), an in silico identification and characterization of prdm1-like genes has been undertaken, confirming that prdm1 and znf683 evolved from a common ancestor gene, acquiring three gene copies after the teleost-specific whole genome duplication event (WGD) and six genes after the salmonid-specific WGD. Additional transcriptional studies to study how each of these genes are regulated in homeostasis, in response to a viral infection or in B cells in different differentiation stages, provide novel insights as to how this gene family evolved and how their encoded products might be implicated in the lymphocyte differentiation process in teleosts.
PB Frontiers
SN 1664-3224
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/97094
UL https://hdl.handle.net/20.500.14352/97094
LA eng
NO Perdiguero, Pedro, et al. «Insights Into the Evolution of the prdm1/Blimp1 Gene Family in Teleost Fish». Frontiers in Immunology, vol. 11, octubre de 2020, p. 596975. https://doi.org/10.3389/fimmu.2020.596975.
NO FundingThis work was supported by the European Research Council (ERC Consolidator Grant 2016 725061 TEMUBLYM), by the Spanish Ministry of Science, Innovation and Universities (project AGL2017-85494-C2-1-R) and by the Comunidad de Madrid (grant 2016-T1/BIO-1672).
NO European Commission
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Comunidad de Madrid
DS Docta Complutense
RD 29 jun 2025