RT Journal Article T1 Circulating nitrate-nitrite reduces oxygen uptake for improving resistance exercise performance after rest time in well-trained CrossFit athletes A1 Garnacho Castaño, Manuel Vicente A1 Sánchez Nuño, Sergio A1 Molina Raya, Lorena A1 Carbonell, Teresa A1 Maté Muñoz, José Luis A1 Pleguezuelos Cobo, Eulogio A1 Serra Paya, Noemi AB This study aimed to determine the effects of circulating nitrate plus nitrite (NOx) concentrations on resistance exercise performance, VO2 and biomarkers of muscle damage. Eleven well-trained male CrossFit athletes (29.2 +/- 3.7 years, 78.9 +/- 5.4 kg, 175.1 +/- 6.3 cm) carried out a resistance exercise test after drinking 140 mL of beetroot juice (BJ) or placebo. The test consisted of repeating the same resistance exercise routine twice: wall ball shots plus full back squat with 3-min rest (1st routine) or without rest (2nd routine) between the two exercises. Higher NOx plasma levels were verified after BJ than placebo in the pretest and post-test (p < 0.001). A higher number of repetitions was observed after BJ intake compared to placebo in the full back squat exercise during the first routine (p = 0.004). A significantly reduced VO2 was detected after BJ intake compared to placebo during rest and full back squat execution in the first routine (p < 0.05). Plasma myoglobin concentrations were significantly increased with BJ compared to placebo (p = 0.036). These results showed that plasma NOx levels reduced VO2 after BJ intake during rest time. These reduced VO2 was a key factor for improving full back squat performance during the first routine. PB Nature Publishing Group YR 2022 FD 2022-06-11 LK https://hdl.handle.net/20.500.14352/129677 UL https://hdl.handle.net/20.500.14352/129677 LA eng NO Garnacho-Castaño, M.V., Sánchez-Nuño, S., Molina-Raya, L. et al. Circulating nitrate-nitrite reduces oxygen uptake for improving resistance exercise performance after rest time in well-trained CrossFit athletes. Sci Rep 12, 9671 (2022). https://doi.org/10.1038/s41598-022-13786-x DS Docta Complutense RD 26 feb 2026