RT Journal Article
T1 Alcohol concentration determines the type of atrial arrhythmia induced in a porcine model of acute alcoholic intoxication.
A1 Almendral Garrote, Jesús
A1 Anadón Baselga, María José
A1 Zaballos García, Matilde
A1 Delcán Domínguez, Juan Luis
A1 Gonzalez Pablo, 
AB Alcohol abuse has long been suspected clinically tocause paroxysmal atrial tachyarrhythmias. However, such a relationship has never been conclusively proven, partly due to the lack of experimental evidence. Although atrial fibrillation (AF) si the most com- mon atrial arrhythmia attributed to acute alcoholic ingestion, atrial flutter has occasionally been noted. We analyzed the possible role of alcohol in initiation and/or maintenance of a variety of atrial tachy- arrhythmias in a closed-chest porcine model. Nine pigs underwent nine endocardial right atrial stimula- tion protocols (RASP) at baseline and 17 RASPs after increasing doses of ethanol (first infusion 1,230 mg/kg, second infusion 870 mg/kg) by means of one multipolar catheter advanced under heavy sedation from the femoral vein. Each RASP included 1, 2, and 3extrastimuli, and rapid pacing at 5 times diastolic threshold. Venous ethanol concentrations were measured (HPGC method) every 10 minutes and at the time of arrhythmia induction. Atrial tachvarrhythmias were induced in 4 of 9 baseline RASPs, and lastedfor a mean of 21 seconds, and in 16 of 71 RASPs after alcohol lasting for a mean of 357 seconds. Only fib- rillation was observed at the baseline RASP. The atrial tachyarrhythmias induced after alcohol were AF in 1 RASPs and atrial flutter in 5 RASPs (in 5 animals). The mean venous ethanol concentration at thetime of the longest arrhythmia induced for each RASP were 200 $ 89 mg/dL for RASP inducing fibrilla- tion and 292 ≤40 mg/dL for RASP inducing flutter (P < 0.05). Flutter tended to be sustained (> 1 minute in duration) more often than fibrillation (4 of 5 flutter vs 2 of 1 fibrillation P < 0.05). In three experiments, atrial flutter persisted for >10 minutes and was terminated by overdrive atrial pacing. We concluded: (1) in this closed-chest porcine model, an ethanol infusion facilitates a variety of atrial arrhythmias related to the ethanol concentration; (2) flutter tended to be sustained, and its termination by overdrive pacing suggests the possibility of an alcohol induced reentrant mechanism; and (3) the higher concentration re- quired for atrial flutter, exceeding that usually seen in humans, may help to explain the rarity of atrial flutter in clinical alcohol intoxication. (PACE 1996; 19(Pt. II):1962-1967)
SN 1540-8159
YR 1996
FD 1996
LK https://hdl.handle.net/20.500.14352/117073
UL https://hdl.handle.net/20.500.14352/117073
LA eng
NO Anadon MJ, Almendral J, González P, Zaballos M, Delcan JL, De Guevara JL. Alcohol concentration determines the type of atrial arrhythmia induced in a porcine model of acute alcoholic intoxication. Pacing Clin Electrophysiol. 1996 Nov;19(11 Pt 2):1962-7. doi: 10.1111/j.1540-8159.1996.tb03262.x. PMID: 8945078.
DS Docta Complutense
RD 16 abr 2025