RT Journal Article T1 Blood glucose prediction using multi-objective grammatical evolution: analysis of the “agnostic” and “what-if” scenarios A1 Contador, Sergio A1 Colmenar, José Manuel A1 Garnica Alcázar, Antonio Óscar A1 Velasco Cabo, José Manuel A1 Hidalgo Pérez, José Ignacio AB In this paper we investigate the benefits of applying a multi-objective approach for solving a symbolic regression problem by means of Grammatical Evolution. In particular, we extend previous work, obtaining mathematical expressions to model glucose levels in the blood of diabetic patients. Here we use a multi-objective Grammatical Evolution approach based on the NSGA-II algorithm, considering the root-mean-square error and an ad-hoc fitness function as objectives. This ad-hoc function is based on the Clarke Error Grid analysis, which is useful for showing the potential danger of mispredictions in diabetic patients. In this work, we use two datasets to analyse two different scenarios: What-if and Agnostic, the most common in daily clinical practice. In the What-if scenario, where future events are evaluated, results show that the multi-objective approach improves previous results in terms of Clarke Error Grid analysis by reducing the number of dangerous mispredictions. In the Agnostic situation, with no available information about future events, results suggest that we can obtain good predictions with only information from the previous hour for both Grammatical Evolution and Multi-Objective Grammatical Evolution. PB Springer YR 2021 FD 2021 LK https://hdl.handle.net/20.500.14352/117435 UL https://hdl.handle.net/20.500.14352/117435 LA eng NO Contador, S., Colmenar, J.M., Garnica, O. et al. Blood glucose prediction using multi-objective grammatical evolution: analysis of the “agnostic” and “what-if” scenarios. Genet Program Evolvable Mach 23, 161–192 (2022). https://doi.org/10.1007/s10710-021-09424-6 NO Fundación Eugenio Rodríguez Pascual NO Ministerio de Ciencia, Innovación y Universidades(España) NO Comunidad de Madrid DS Docta Complutense RD 19 abr 2025