RT Journal Article
T1 Structural, biochemical, and functional properties of the Rap1-Interacting Adaptor Molecule (RIAM)
A1 Sari Ak, Duygu
A1 Torres Gómez, Álvaro
A1 Yazicioglu, Yavuz Furkan
A1 Christofides, Anthos
A1 Patsoukis, Nikolaos
A1 Lafuente Duarte, María Esther
A1 Boussiotis, Vassiliki A.
AB Leukocytes, the leading players of immune system, are involved in innate and adaptive immune responses. Leukocyte adhesion to endothelial cells during transmigration or to antigen presenting cells during T cell activation, requires integrin activation through a process termed inside-out integrin signaling. In hematopoietic cells, Rap1 and its downstream effector RIAM (Rap1-interacting adaptor molecule) form a cornerstone for inside-out integrin activation. The Rap1/RIAM pathway is involved in signal integration for activation, actin remodeling and cytoskeletal reorganization in T cells, as well as in myeloid cell differentiation and function. RIAM is instrumental for phagocytosis, a process requiring particle recognition, cytoskeletal remodeling and membrane protrusion for engulfment and digestion. In the present review, we discuss the structural and molecular properties of RIAM and the recent discoveries regarding the functional role of the Rap1/RIAM module in hematopoietic cells.
PB Science Direct
SN 2319-4170
YR 2022
FD 2022-04
LK https://hdl.handle.net/20.500.14352/116140
UL https://hdl.handle.net/20.500.14352/116140
LA eng
NO Sari-Ak, D., Torres-Gomez, A., Yazicioglu, Y. F., Christofides, A., Patsoukis, N., Lafuente, E. M., & Boussiotis, V. A. (2022). Structural, biochemical, and functional properties of the Rap1-Interacting Adaptor Molecule (RIAM). Biomedical journal, 45(2), 289–298. https://doi.org/10.1016/j.bj.2021.09.005
NO National Institutes of Health (USA)
DS Docta Complutense
RD 11 abr 2025