RT Journal Article
T1 Freeze-dried cylinders carrying chitosan nanoparticles for vaginal peptide delivery
A1 Marciello, Marzia
A1 Rossi, Silvia
A1 Caramella, Carla
A1 Remuñán-López, Carmen
AB Recently nanoparticle-based vaginal drug delivery formulations have been acquiring great attention for the administration of peptide based-vaccines or microbicides to prevent or treat sexually transmitted diseases. In this work, a straightforward and efficient strategy for the vaginal application and release of peptideloaded mucoadhesive nanoparticles was developed. This essentially consists of chitosan nanoparticles encapsulated in suitable hydrophilic freeze-dried cylinders. Chitosan nanoparticles are responsible for carrying the peptide drug and allowing adhesion to the vaginal mucosal epithelium. Hydrophilic freezedried cylinders facilitate the application and quick release of the nanoparticles to the vaginal zone. Upon contact with the aqueous vaginal medium, the excipients constituting these sponge-like systems are quickly dissolved enabling the release of their content. In vitro release studies showed the ability of the sponge-like systems and chitosan nanoparticles to deliver the mucoadhesive nanoparticles and peptide respectively. CLSM micrographs proved the nanoparticles ability promoting the peptide penetration inside the vaginal mucosa.
SN 0144-8617
YR 2017
FD 2017-08
LK https://hdl.handle.net/20.500.14352/100767
UL https://hdl.handle.net/20.500.14352/100767
LA eng
NO Marciello, Marzia, et al. «Freeze-Dried Cylinders Carrying Chitosan Nanoparticles for Vaginal Peptide Delivery». Carbohydrate Polymers, vol. 170, agosto de 2017, pp. 43-51. DOI.org (Crossref), https://doi.org/10.1016/j.carbpol.2017.04.051.
NO Instituto de Salud Carlos III
NO Xunta de Galicia
DS Docta Complutense
RD 9 abr 2025