TY - JOUR AU - Palomino-Cano, Carmen AU - Mera-Delgado, M.Carmen AU - Pons, Ramon AU - Moreno, Esther AU - Larrea, Esther AU - Aguirre, Lecnia AU - Mamani, Elisa AU - Martínez-Ohárriz, M.Cristina AU - Irache, Juan M. AU - Carrión Herrero, Francisco Javier AU - Espuelas, Socorro PY - 2026 DO - 10.1016/j.ijpharm.2025.126444 SN - 0378-5173 UR - https://hdl.handle.net/20.500.14352/129493 T2 - International Journal of Pharmaceutics AB - TLR7 agonists are low molecular weight immunomodulators that can rapidly diffuse from the site of administration, often leading to undesired systemic inflammatory effects. To mitigate toxicity and broaden therapeutic applicability, imiquimod (IMQ), a... LA - eng M2 - 1 PB - Elsevier KW - Factorial design KW - Imiquimod KW - Lipid nanoparticles KW - Macrophages TI - Fluidity as a key determinant of stability in PEGylated lipid nanoparticles loaded with a TLR7 agonist TY - journal article VL - 688 ER -