RT Journal Article
T1 New trends in the biocatalytic production of nucleosidic active pharmaceutical ingredients using 2′-deoxyribosyltransferases
A1 Del Arco, Jon
A1 Acosta, Javier
A1 Fernández Lucas, Jesús
AB Nowadays, pharmaceutical industry demands competitive and eco-friendly processes for active pharmaceutical ingredients (APIs) manufacturing. In this context, enzyme and whole-cell mediated processes offer an efficient, sustainable and cost-effective alternative to the traditional multi-step and environmentally-harmful chemical processes. Particularly, 2′-deoxyribosyltransferases (NDTs) have emerged as a novel synthetic alternative, not only to chemical but also to other enzyme-mediated synthetic processes. This review describes recent findings in the development and scaling up of NDTs as industrial biocatalysts, including the most relevant and recent examples of single enzymatic steps, multienzyme cascades, chemo-enzymatic approaches, and engineered biocatalysts. Finally, to reflect the inventive and innovative steps of NDT-mediated bioprocesses, a detailed analysis of recently granted patents, with specific focus on industrial synthesis of nucleoside-based APIs, is hereunder presented.
PB Elsevier
SN 0734-9750
YR 2021
FD 2021-11
LK https://hdl.handle.net/20.500.14352/109108
UL https://hdl.handle.net/20.500.14352/109108
LA eng
NO Del Arco J, Acosta J, Fernández-Lucas J. New trends in the biocatalytic production of nucleosidic active pharmaceutical ingredients using 2′-deoxyribosyltransferases. Biotechnology Advances 2021;51:107701. https://doi.org/10.1016/j.biotechadv.2021.107701.
NO Fundación Santander
DS Docta Complutense
RD 11 abr 2025