%0 Journal Article
%A Marín-Royo, Gema
%A Ortega-Hernández, Adriana
%A Martínez Martínez, Ernesto
%A Jurado-López, Raquel
%A Luaces, María
%A Islas, Fabian
%A Gómez-Garre, Dulcenombre
%A Lagunas, Esther
%A Ramchandani, Bunty
%A García-Bouza, Mónica
%A Nieto, María Luisa
%A Cachofeiro Ramos, María Victoria
%T The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction
%D 2019
%@ 2045-2322
%U https://hdl.handle.net/20.500.14352/115420
%X Cardiac lipotoxicity is involved in the cardiac functional consequences associated with obesity.Therefore, the aim of this study was to explore whether changes in the mitochondrial lipid cardiacprofle could refect diferences in cardiac function and structure in obese and non-obese rats withmyocardial infarction (MI). Whether these changes can also be refected in a specifc plasma miRNAsignature as markers of cardiac damage was also evaluated. Rats were fed with either standard (3.5%fat) or high fat diet (35% fat) for 6 weeks before the induction of MI and sacrifced 4 weeks later. MIshowed cardiac lipotoxicity independently of the presence of obesity, although obese and non-obeserats did not present the same cardiac lipid profle at mitochondrial level. Several cardiac lipid species inmitochondria, including cardiolipins and triglycerides, were associated with myocardial fbrosis, withmitochondrial triglyceride levels being independently associated with it; this supports that lipotoxicitycan afect cardiac function. MI down-regulated plasma levels of miRNA 15b-5p and 194-5p in obese andnon-obese animals, which were associated with cardiac function, mitochondrial lipids and myocardialfbrosis, with miRNA 15b-5p levels being independently associated with cardiac fbrosis. This couldsupport that lipotoxicity could afect heart function by modulating plasma miRNAs.
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