RT Journal Article
T1 The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction
A1 Marín-Royo, Gema
A1 Ortega-Hernández, Adriana
A1 Martínez Martínez, Ernesto
A1 Jurado-López, Raquel
A1 Luaces, María
A1 Islas, Fabian
A1 Gómez-Garre, Dulcenombre
A1 Lagunas, Esther
A1 Ramchandani, Bunty
A1 García-Bouza, Mónica
A1 Nieto, María Luisa
A1 Cachofeiro Ramos, María Victoria
AB Cardiac lipotoxicity is involved in the cardiac functional consequences associated with obesity.Therefore, the aim of this study was to explore whether changes in the mitochondrial lipid cardiacprofle could refect diferences in cardiac function and structure in obese and non-obese rats withmyocardial infarction (MI). Whether these changes can also be refected in a specifc plasma miRNAsignature as markers of cardiac damage was also evaluated. Rats were fed with either standard (3.5%fat) or high fat diet (35% fat) for 6 weeks before the induction of MI and sacrifced 4 weeks later. MIshowed cardiac lipotoxicity independently of the presence of obesity, although obese and non-obeserats did not present the same cardiac lipid profle at mitochondrial level. Several cardiac lipid species inmitochondria, including cardiolipins and triglycerides, were associated with myocardial fbrosis, withmitochondrial triglyceride levels being independently associated with it; this supports that lipotoxicitycan afect cardiac function. MI down-regulated plasma levels of miRNA 15b-5p and 194-5p in obese andnon-obese animals, which were associated with cardiac function, mitochondrial lipids and myocardialfbrosis, with miRNA 15b-5p levels being independently associated with cardiac fbrosis. This couldsupport that lipotoxicity could afect heart function by modulating plasma miRNAs.
PB Nature Portfolio
SN 2045-2322
YR 2019
FD 2019-01-24
LK https://hdl.handle.net/20.500.14352/115420
UL https://hdl.handle.net/20.500.14352/115420
LA eng
NO Marín-Royo G, Ortega-Hernández A, Martínez-Martínez E, Jurado-López R, Luaces M, Islas F, Gómez-Garre D, Delgado-Valero B, Lagunas E, Ramchandani B, García-Bouza M, Nieto ML, Cachofeiro V. The Impact of Cardiac Lipotoxicity on Cardiac Function and Mirnas Signature in Obese and Non-Obese Rats with Myocardial Infarction.Sci Rep. 2019 Jan 24;9(1):444. doi: 10.1038/s41598-018-36914-y
NO ISCIII
NO Ministerio de Economia y Competitividad
NO Sociedad Española de Cardiología
DS Docta Complutense
RD 8 abr 2025