TY - JOUR AU - Amieva, Rafael AU - Coronado, Montserrat AU - Powell, Jessica AU - Arranz Solís, David AU - Hassan, Musa A. AU - Collantes Fernández, Esther AU - Ortega Mora, Luis Miguel AU - Horcajo Iglesias, María Del Pilar PY - 2025 DO - 10.3389/fimmu.2025.1617570 UR - https://hdl.handle.net/20.500.14352/124760 T2 - Frontiers in Immunology AB - IntroductionNeospora caninum is an apicomplexan parasite responsible for bovine neosporosis, a major cause of abortion in cattle worldwide. N. caninum rhoptry protein 2 (NcROP2) has been identified as an essential factor in host cell invasion and... LA - eng M2 - 1 PB - Frontiers Media KW - BALB/c KW - CRISPR/Cas9 KW - NcROP2 KW - Neospora caninum KW - Bovine macrophages KW - Transcriptome KW - Virulence factor TI - NcROP2 deletion reduces Neospora caninum virulence by altering parasite stage differentiation and hijacking host immune response TY - journal article VL - 16 ER -