RT Journal Article
T1 The ratio of prematurely aging to non-prematurely aging mice cohabiting, conditions their behavior, immunity and lifespan
A1 Garrido Tarrio, Antonio
A1 Cruces, Julia
A1 Ceprián, Noemí
A1 Díaz del Cerro, E.
A1 Félix, J.
A1 Fuente del Rey, Mónica de la
AB Adult prematurely aging mice (PAM) show behavioral deterioration, premature immunosenescence and increased oxidative stress, impairments that are associated with their shorter lifespan, compared to the corresponding exceptional non-prematurely aging mice (ENPAM). When PAM live in a predominantly ENPAM environment (2/5, respectively) they exhibit an improvement of immunity and redox state in their spleen and thymus leukocytes, and an increased lifespan. Nevertheless, it is unknown if other PAM/ENPAM ratios could affect behavioral and peritoneal leukocyte functions of PAM and change their lifespan. ENPAM and PAM were divided into the following groups: C-ENPAM (8 ENPAM in the cage); C-PAM (8 PAM in the cage); ENPAM > 50% and PAM < 50% (5 ENPAM/2 PAM in each cage); ENPAM = 50% and PAM = 50% (4 ENPAM/ 4 PAM in each cage), and PAM > 50% and ENPAM < 50% (5 PAM/2 ENPAM in each cage). After two months, mice were submitted to a battery of behavioral tests. Several functions and oxidative stress parameters were then assessed in their peritoneal leukocytes. Animals were maintained in these conditions to analyze their lifespan. The results showed that PAM > 50%, PAM = 50% and PAM < 50% exhibited better behavioral responses, immunity and redox states in their peritoneal leukocytes than C-PAM. This improvement was higher when the number of ENPAM in the cage was increased, with most of the parameters in PAM < 50% reaching similar values to those in C-ENPAM, and an increased lifespan. However, ENPAM that cohabited with PAM showed, in general, an impairment of parameters studied. In conclusion, the PAM/ENPAM cohabitation ratio is relevant to behavior and immunity
PB Elsevier
SN 0165-5728, ESSN: 1872-8421
YR 2020
FD 2020-04-10
LK https://hdl.handle.net/20.500.14352/6307
UL https://hdl.handle.net/20.500.14352/6307
LA eng
NO Instituto de Salud Carlos III (ISCIII)/Fondo Europeo de Desarrollo Regional(FEDER)
NO Universidad Complutense de Madrid (UCM)
DS Docta Complutense
RD 6 oct 2024