RT Journal Article
T1 The Clinical outcomes, healthcare resource utilization, and related costs (COHERENT) model. Application in heart failure patients
A1 Bueno Zamora, Héctor José
A1 Bernal, José L.
A1 Jiménez Jiménez, Víctor
A1 Martín Sánchez, Francisco Javier
A1 Rossello, Xavier
A1 Moreno Muñoz, Guillermo
A1 Goñi, Clara
A1 Gil, Víctor
A1 Llorens, Pere
A1 Naranjo, Nerea
A1 Jacob, Javier
A1 Herrero Puente, Pablo
A1 Garrote, Sergio
A1 Silla Castro, Juan Carlos
A1 Pocock, Stuart J.
A1 Miró, Òscar
AB Introduction and objectives: Composite endpoints are widely used but have several limitations. The Clinical outcomes, healthcare resource utilization and related costs (COHERENT) model is a new approach for visually displaying and comparing composite endpoints including all their components (incidence, timing, duration) and related costs. We aimed to assess the validity of the COHERENT model in a patient cohort. Methods: A color graphic system displaying the percentage of patients in each clinical situation (vital status and location: at home, emergency department [ED] or hospital) and related costs at each time point during follow-up was created based on a list of mutually exclusive clinical situations coded in a hierarchical fashion. The system was tested in a cohort of 1126 patients with acute heart failure from 25 hospitals. The system calculated and displayed the time spent in each clinical situation and health care resource utilization-related costs over 30 days. Results: The model illustrated the times spent over 30 days (2.12% in ED, 23.6% in index hospitalization, 2.7% in readmissions, 65.5% alive at home, and 6.02% dead), showing significant differences between patient groups, hospitals, and health care systems. The tool calculated and displayed the daily and cumulative health care-related costs over time (total, €4 895 070; mean, €144.91 per patient/d). Conclusions: The COHERENT model is a new, easy-to-interpret, visual display of composite endpoints, enabling comparisons between patient groups and cohorts, including related costs. The model may constitute a useful new approach for clinical trials or observational studies, and a tool for benchmarking, and value-based health care.
PB Elsevier
SN 1885-5857
YR 2022
FD 2022-07
LK https://hdl.handle.net/20.500.14352/109746
UL https://hdl.handle.net/20.500.14352/109746
LA spa
NO Bueno H, Bernal JL, Jiménez-Jiménez V, Martín-Sánchez FJ, Rossello X, Moreno G, et al. The Clinical outcomes, healthcare resource utilization, and related costs (COHERENT) model. Application in heart failure patients. Revista Espanola de Cardiologia. 2022;75(7):585-94.
DS Docta Complutense
RD 20 ene 2026