RT Journal Article
T1 Microglial HO‐1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects
A1 Parada, Esther
A1 Buendia, Izaskun
A1 Navarro González De Mesa, Elisa
A1 Avendaño, Carlos
A1 Egea, Javier
A1 García López, Manuela
AB Scope: We have studied if curcumin can protect glial cells under an oxidative stress and inflammatory environment, which is known to be deleterious in neurodegeneration.Methods and results: Primary rat glial cultures exposed to the combination of an oxidative (rotenone/oligomycin A) and a proinflammatory LPS stimuli reduced by 50% glial viability. Under these experimental conditions, curcumin afforded significant glial protection and reduction of reactive oxygen species; these effects were blocked by the HO-1 inhibitor tin protoporphyrin-IX (SnPP). These findings correlate with the observation that curcumin induced the antioxidative protein HO-1. Most interesting was the observation that the glial protective effects related to HO-1 induction were microglial specific as shown in glial cultures from LysM(Cre) Hmox(∆/∆) mice where curcumin lost its protective effect. Under LPS conditions, curcumin reduced the microglial proinflammatory markers iNOS and tumor necrosis factor, but increased the anti-inflammatory cytokine IL4. Analysis of the microglial phenotype showed that curcumin favored a ramified morphology toward a microglial alternative activated state against LPS insult also by a HO-1-dependent mechanism.Conclusion: The curry constituent curcumin protects glial cells and promotes a microglial anti-inflammatory phenotype by a mechanism that implicates HO-1 induction; these effects may have impact on brain protection under oxidative and inflammatory conditions.
PB Wiley
SN 1613-4125
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/93303
UL https://hdl.handle.net/20.500.14352/93303
LA eng
NO Parada E, Buendia I, Navarro E, Avendaño C, Egea J, López MG. Microglial HO-1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects. Mol Nutr Food Res. 2015 Sep;59(9):1690-700. doi: 10.1002/mnfr.201500279
DS Docta Complutense
RD 7 abr 2025