RT Journal Article
T1 Bacterial Translocation to Mesenteric Lymph Nodes Increases in Chronic Portal Hypertensive Rats
A1 Llamas Matías, Miguel Ángel
A1 Aller Reyero, María De Los-Ángeles
A1 Marquina Díaz, Domingo
A1 Nava Hidalgo, María Paz
A1 Arias Pérez, Jaime
AB Purpose: Bacterial translocation is a frequent complication in portal hypertension related to cirrhosis in the human clinical area. The aim of this study was to verify the existence of intestinal bacterial translocation to mesenteric lymph nodes in male Wistar rats with triple partial portal vein ligation during short- (48 h) and long-term (1 month) postoperative evolution. Results: At 48 h, ileal total aerobes bacteria (p < 0.001) and Lactobacillus decrease in sham-operated (SO) and portal hypertensive (PH) rats. At 1 month, ileal Enterococci and Streptococcus sp. show a statistically significant decrease in SO- and PH-rats. Lactobacillus decreases in the colon in SO- (p < 0.01) and in PH-rats (p < 0.001). At 1 month, colonic Enterococci decreases compared to control (p < 0.001) and SO-rats (p < 0.01). These intestinal microfloral changes are associated with bacterial translocation to mesenteric lymph nodes at 48 h (50%; p = 0.004) and 1 month (100%; p < 0.001) of postoperative evolution in PH-rats. Conclusions: The enlargement of the stenosed portal tract related to triple partial portal vein ligation in the rat, since it increases the resistance to the portal blood flow, may be a key factor involved in one of the pathological consequences of portal hypertension, as is bacterial translocation to mesenteric lymph nodes. © 2009 Springer Science+Business Media, LLC.
PB Springer
SN 0163-2116
SN 1573-2568
YR 2009
FD 2009-10-16
LK https://hdl.handle.net/20.500.14352/107697
UL https://hdl.handle.net/20.500.14352/107697
LA eng
NO Llamas, M.-Á., Aller, M.-Á., Marquina, D., Nava, M.-P., & Arias, J. (2010). Bacterial translocation to mesenteric lymph nodes increases in chronic portal hypertensive rats. Digestive Diseases and Sciences, 55(8), 2244-2254. https://doi.org/10.1007/s10620-009-1001-3
NO MMA Foundation
NO Instituto de Ciencias de la Salud
NO Junta de Castilla-La Mancha
DS Docta Complutense
RD 14 dic 2025