RT Journal Article
T1 Direct proton range verification using oxygen-18 enriched water as a contrast agent
A1 España Palomares, Samuel
A1 Sánchez Parcerisa, Daniel
A1 Ibáñez García, Paula Beatriz
A1 Sánchez Tembleque Verbo, Víctor
A1 Udías Moinelo, José Manuel
A1 Valladolid Onecha, Víctor
A1 Gutiérrez Uzquiza, Álvaro
A1 Bäcker, Claus Maximilian
A1 Bäumer, Christian
A1 Herrmann, Ken
A1 Fragoso Costa, Pedro
A1 Timmermann, Beate
A1 Fraile Prieto, Luis Mario
AB We propose the use of O-enriched water as a suitable contrast agent for potential in-vivo range verification in proton therapy. The low energy production threshold of 18F (2.6 MeV, proton range in water of 115 μm) leads to tissue activation in very close proximity to the maximum dose deposition, facilitating accurate range verification with off-line PET imaging. This idea has been explored in a phantom experiment. A 3D-printed phantom containing inserts with 18Oenriched water was irradiated with a 100-MeV, 8 × 8 cm2 proton beam, and the induced activity was measured with a small-animal PET-CT 30 min after irradiation. The images obtained were compared against Monte Carlo simulation using TOPAS. Good agreement was observed between reconstructed and simulated activity profiles (within 40% for specific 18F activity), with excellent spatial match to the simulated dose deposition. Because of the long half-life of 18F, the specific activity of the contrast agent could be separated and was clearly observed for more than 2 h after irradiation. Activity distribution maps were used to determine the position of the Bragg peak within 2 mm for three different regions of interest. These results show the potential of 18O-enriched water as a contrast agent in proton therapy.
PB Elsevier
SN 0969-806X
YR 2021
FD 2021-02-08
LK https://hdl.handle.net/20.500.14352/6831
UL https://hdl.handle.net/20.500.14352/6831
LA eng
NO España Palomares, S., Sánchez Parcerisa, D., Ibáñez García, P. B. et al. «Direct Proton Range Verification Using Oxygen-18 Enriched Water as a Contrast Agent». Radiation Physics and Chemistry, vol. 182, mayo de 2021, p. 109385. DOI.org (Crossref), https://doi.org/10.1016/j.radphyschem.2021.109385.
NO CRUE-CSIC (Acuerdos Transformativos 2021)
NO Unión Europea
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Comunidad de Madrid
NO Comunidad de Madrid/Fondo Europeo de Desarrollo Regional
NO Centro de Excelencia Severo Ochoa
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 11 abr 2025