RT Journal Article
T1 Optomagnetic nanofluids for controlled brain hyperthermia: a critical study
A1 Méndez González, Diego
A1 Lifante, José
A1 Zabala Gutiérrez, Irene
A1 Marin, Riccardo
A1 Ximendes, Erving
A1 Sanz-de Diego, Elena
A1 Iglesias-de la Cruz, M. Carmen
A1 Teran, Francisco J.
A1 Rubio Retama, Benito Jorge
A1 Jaque, Daniel
AB Optomagnetic nanofluids (OMNFs) are colloidal dispersions of nanoparticles (NPs) with combined magnetic and optical properties. They are especially appealing in biomedicine since they can be used as minimally invasive platforms for controlled hyperthermia treatment of otherwise difficultly accessible tumors such as intracranial ones. On the one hand, magnetic NPs act as heating mediators when subjected to alternating magnetic fields or light irradiation. On the other hand, suitably tailored luminescent NPs can provide a precise and remote thermal readout in real time. The combination of heating and thermometric properties allows, in principle, to precisely monitor the increase in the temperature of brain tumors up to the therapeutic level, without causing undesired collateral damage. In this work we demonstrate that this view is an oversimplification since it ignores the presence of relevant interactions between magnetic (γ-Fe2O3 nanoflowers) and luminescent nanoparticles (Ag2S NPs) that result in a detrimental alteration of their physicochemical properties. The magnitude of such interactions depends on the interparticle distance and on the surface properties of nanoparticles. Experiments performed in mouse brains (phantoms and ex vivo) revealed that OMNFs cannot induce relevant heating under alternating magnetic fields and fail to provide reliable temperature reading. In contrast, we demonstrate that the use of luminescent nanofluids (containing only Ag2S NPs acting as both photothermal agents and nanothermometers) stands out as a better alternative for thermally monitored hyperthermia treatment of brain tumors in small animal models.
PB ROYAL SOCIETY OF  CHEMISTRY. THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
SN 2040-3364
YR 2022
FD 2022-10-16
LK https://hdl.handle.net/20.500.14352/101176
UL https://hdl.handle.net/20.500.14352/101176
LA eng
NO Mendez-Gonzalez D, Lifante J, Zabala Gutierrez I, Marin R, Ximendes E, Sanz-de Diego E, et al. Optomagnetic nanofluids for controlled brain hyperthermia: a critical study. Nanoscale 2022;14:16208–19. https://doi.org/10.1039/D2NR03413A.
NO Comunidad de Madrid
NO European Commission
NO Ministerio de Economía, Comercio y Empresa (España)
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Horizon 2020
NO Instituto Ramón y Cajal de Investigación Sanitaria
DS Docta Complutense
RD 17 jul 2024