RT Journal Article
T1 Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways
A1 Bajo Grañeras, Raquel
A1 Martín Herranz, Ricardo
A1 Moratalla, Rosario
A1 Perea, Gertrudis
A1 Araque, Alfonso
AB Astrocytes are important regulatory elements in brain function. They respond to neurotransmitters and release gliotransmitters that modulate synaptic transmission. However, the cell- and synapse-specificity of the functional relationship between astrocytes and neurons in certain brain circuits remains unknown. In the dorsal striatum, which mainly comprises two intermingled subtypes (striatonigral and striatopallidal) of medium spiny neurons (MSNs) and synapses belonging to two neural circuits (the direct and indirect pathways of the basal ganglia), subpopulations of astrocytes selectively responded to specific MSN subtype activity. These subpopulations of astrocytes released glutamate that selectively activated N-methyl-d-aspartate receptors in homotypic, but not heterotypic, MSNs. Likewise, astrocyte subpopulations selectively regulated homotypic synapses through metabotropic glutamate receptor activation. Therefore, bidirectional astrocyte-neuron signaling selectively occurs between specific subpopulations of astrocytes, neurons, and synapses.
PB American Association for the Advancement of Science
SN 0036-8075
YR 2015
FD 2015
LK https://hdl.handle.net/20.500.14352/97035
UL https://hdl.handle.net/20.500.14352/97035
LA eng
NO R. Martín et al. ,Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways.Science349,730-734(2015).DOI:10.1126/science.aaa7945
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 7 abr 2025