RT Journal Article
T1 Vagus Nerve Stimulation: A Personalized Therapeutic Approach for Crohn’s and Other Inflammatory Bowel Diseases
A1 Cirillo, Giovanni
A1 Negrete Díaz, Flor
A1 Yucuma, Daniela
A1 Virtuoso, Assunta
A1 Sohaib, Korai Ali
A1 De Luca, Ciro
A1 Kaniusas, Eugenijus
A1 Papa, Michele
A1 Panetsos Petrova, Fivos
AB Inflammatory bowel diseases, including Crohn’s disease and ulcerative colitis, are incurable autoimmune diseases characterized by chronic inflammation of the gastrointestinal tract. There is increasing evidence that inappropriate interaction between the enteric nervous system and central nervous system and/or low activity of the vagus nerve, which connects the enteric and central nervous systems, could play a crucial role in their pathogenesis. Therefore, it has been suggested that appropriate neuroprosthetic stimulation of the vagus nerve could lead to the modulation of the inflammation of the gastrointestinal tract and consequent long-term control of these autoimmune diseases. In the present paper, we provide a comprehensive overview of (1) the cellular and molecular bases of the immune system, (2) the way central and enteric nervous systems interact and contribute to the immune responses, (3) the pathogenesis of the inflammatory bowel disease, and (4) the therapeutic use of vagus nerve stimulation, and in particular, the transcutaneous stimulation of the auricular branch of the vagus nerve. Then, we expose the working hypotheses for the modulation of the molecular processes that are responsible for intestinal inflammation in autoimmune diseases and the way we could develop personalized neuroprosthetic therapeutic devices and procedures in favor of the patients.
PB MDPI
SN 2073-4409
YR 2022
FD 2022-12-17
LK https://hdl.handle.net/20.500.14352/73173
UL https://hdl.handle.net/20.500.14352/73173
LA eng
NO Received: 25 August 2022; Accepted: 13 December 2022; Published: 17 December 2022
NO REgión de Campania (Italia)
NO Ministerio de Investigación y Universidades de Italia
DS Docta Complutense
RD 5 abr 2025