RT Journal Article
T1 Eph/ephrins-mediated thymocyte–thymic epithelial cellinteractions control numerous processes of thymus biology
A1 García Ceca Hernández, Javier
A1 Alfaro Sánchez, David
A1 Montero Herradón, Sara
A1 Tobajas, Esther
A1 Muñoz, Juan José
A1 Zapata González, Agustín
AB Numerous studies emphasize the relevance of thymocyte–thymic epithelial cell (TECs) interactions for the functional maturation of intrathymic T lymphocytes. The tyrosine kinase receptors, Ephs (erythropoietin-producing hepatocyte kinases) and their ligands, ephrins (Eph receptor interaction proteins), are molecules known to be involved in the regulation of numerous biological systems in which cell-to-cell interactions are particularly relevant. In the last years, we and other authors have demonstrated the importance of these molecules in the thymic functions and the T-cell development. In the present report, we review data on the effects of Ephs and ephrins in the functional maturation of both thymic epithelial microenvironment and thymocyte maturation as well as on their role in the lymphoid progenitor recruitment into the thymus.
PB Frontiers Media
SN 1664-3224
YR 2015
FD 2015-06-26
LK https://hdl.handle.net/20.500.14352/23221
UL https://hdl.handle.net/20.500.14352/23221
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Ministerio de Salud (España)
DS Docta Complutense
RD 29 abr 2024