RT Journal Article
T1 Complement C3F allotype synthesized by liver recipient modifies transplantation outcome independently from donor hepatic C3.
A1 Valero Hervás, Diana María
A1 Sánchez Zapardiel, Elena
A1 Castro Panete, María José
A1 Gallego Bustos, Fernando
A1 Cambra Molero, Félix
A1 Justo Alonso, Iago
A1 Laguna Goya, Rocío
A1 Jiménez Romero, Luis Carlos
A1 Moreno González, Enrique
A1 López Medrano, Francisco
A1 San Juan Garrido, Rafael
A1 Fernández Ruiz, Mario
A1 Aguado García, José María
A1 Paz Artal, Estela Natividad
AB Complement component 3 (C3) presents both slow (C3S) and fast (C3F) variants, which can be locally produced and activated by immune system cells. We studied C3 recipient variants in 483 liver transplant patients by RT-PCR-HRM to determine their effect on graft outcome during the first year post-transplantation. Allograft survival was significantly decreased in C3FF recipients (C3SS 95% vs C3FS 91% vs C3FF 83%; P=.01) or C3F allele carriers (C3F absence 95% vs C3F presence 90%, P=.02). C3FF genotype or presence of C3F allele independently increased risk for allograft loss (OR: 2.38, P=.005 and OR: 2.66, P=.02, respectively). C3FF genotype was more frequent among patients whose first infection was of viral etiology (C3SS 13% vs C3FS 18% vs C3FF 32%; P=.04) and independently increased risk for post-transplant viral infections (OR: 3.60, P=.008). On the other hand, C3FF and C3F protected from rejection events (OR: 0.54, P=.03 and OR: 0.63, P=.047, respectively). Differences were not observed in hepatitis C virus recurrence or patient survival. In conclusion, we show that, independently from C3 variants produced by donor liver, C3F variant from recipient diminishes allograft survival, increases susceptibility to viral infections, and protects from rejection after transplantation. C3 genotyping of liver recipients may be useful to stratify risk.
PB Wiley
SN 0902-0063
YR 2016
FD 2016-11-01
LK https://hdl.handle.net/20.500.14352/98787
UL https://hdl.handle.net/20.500.14352/98787
LA eng
NO Valero-Hervás DM, Sánchez-Zapardiel E, Castro MJ, Gallego-Bustos F, Cambra F, Justo I, Laguna-Goya R, Jiménez-Romero C, Moreno E, López-Medrano F, San Juan R, Fernández-Ruiz M, Aguado JM, Paz-Artal E. Complement C3F allotype synthesized by liver recipient modifies transplantation outcome independently from donor hepatic C3. Clin Transplant. 2017 Jan;31(1). doi: 10.1111/ctr.12866
DS Docta Complutense
RD 6 abr 2025