RT Journal Article
T1 Oxidative and Molecular-Structural Alterations of Spermatozoa in Swine and Ram Exposed to the Triazole Ipconazole
A1 Falero, Cristian
A1 Huanca, Wilfredo
A1 Barrios Arpi, Luis
A1 Lira Mejía, Boris
A1 Ramos-Coaguila, Olger
A1 Torres, Edith
A1 Ramos Alonso, Eva
A1 Romero Martínez, Manuel Alejandro
A1 Ramos Gonzalez, Mariella
AB Triazole pesticides are widely used throughout the world, but their abuse causes toxic effects in non-targeted organisms. In the present study, the cytotoxic effect of the triazole ipconazole was evaluated in porcine and ram spermatozoa. Ipconazole significantly reduced sperm viability, increased ROS levels, altered catalase and SOD enzyme activity, and caused alterations in the molecular mRNA expression of structural biomarkers (PRM1, ODF2, AKAP4, THEG, SPACA3 and CLGN) related to fertility in males, as well as the overexpression of BAX (cell death) and ROMO1 (oxidative stress) mRNA. Our results indicate that the fungicide triazole is involved in cellular, enzymatic and molecular alteration of porcine and ram spermatozoa, and is possibly a factor in the development of infertility in male mammals
PB MDPI
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/119760
UL https://hdl.handle.net/20.500.14352/119760
LA eng
NO Falero, C., Huanca, W., Barrios-Arpi, L., Lira-Mejía, B., Ramos-Coaguila, O., Torres, E., Ramos, E., Romero, A., & Ramos-Gonzalez, M. (2025). Oxidative and Molecular-Structural Alterations of Spermatozoa in Swine and Ram Exposed to the Triazole Ipconazole. Toxics, 13(3), 176. https://doi.org/10.3390/toxics13030176
NO Author Contributions: Conceptualization, W.H., E.T. and M.R.-G.; Data curation, L.B.-A.; Formal analysis, B.L.-M., A.R. and and E.R.; Funding acquisition, M.R.-G.; Investigation, C.F., B.L.-M., L.B.-A., O.R.-C., E.T. and M.R.-G.; Methodology, C.F., O.R.-C., E.T. and A.R.; Project administration, M.R.-G.; Resources, W.H., B.L.-M. and O.R.-C.; Software, A.R.; Validation, M.R.-G.; Visualization, W.H., L.B.-A.
NO National University of San Marcos (Italia)
DS Docta Complutense
RD 19 mar 2026