RT Journal Article
T1 Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
A1 Arcos Navarrete, Daniel
A1 Portolés Pérez, María Teresa
AB Research in nanomaterials with applications in bone regeneration therapies has experienced a very significant advance with the development of bioactive mesoporous nanoparticles (MBNPs). These nanomaterials consist of small spherical particles that exhibit chemical properties and porous structures that stimulate bone tissue regeneration, since they have a composition similar to that of conventional sol–gel bioactive glasses and high specific surface area and porosity values. The rational design of mesoporosity and their ability to incorporate drugs make MBNPs an excellent tool for the treatment of bone defects, as well as the pathologies that cause them, such as osteoporosis, bone cancer, and infection, among others. Moreover, the small size of MBNPs allows them to penetrate inside the cells, provoking specific cellular responses that conventional bone grafts cannot perform. In this review, different aspects of MBNPs are comprehensively collected and discussed, includingsynthesis strategies, behavior as drug delivery systems, incorporation of therapeutic ions, formation of composites, specific cellular response and, finally, in vivo studies that have been performed to date.
SN 1661-6596
YR 2023
FD 2023-01-21
LK https://hdl.handle.net/20.500.14352/101671
UL https://hdl.handle.net/20.500.14352/101671
LA eng
NO Ministerio de Economía y Competitividad
NO Fondo Europeo de Desarrollo Regional (FEDER)
NO Agencia Estatal de Investigación (AEI)
NO Ministerio de Ciencia e Innovación
DS Docta Complutense
RD 22 jul 2024