RT Journal Article
T1 Lipidomic profiling of chorionic villi in the placentas of women with chronic venous disease
A1 Ortega, Miguel Angel et al.
A1 Bravo Arribas, Coral
A1 Asúnsolo, Ángel
A1 Coca Menchero, Santiago
AB Background: Chronic venous disease (CVD) is a prevalent lower limb venous pathology that especially affects women, who also show an increased risk of this disease during pregnancy. Studies have shown significant structural changes in the placentas of women with CVD and several markers of tissue damage have been also described. Patients and Methods: To try to understand the different placental pathologies, research efforts have focused on examining metabolomic profiles as indicators of the repercussions of these vascular disorders. This study examines changes produced in the metabolomic profiles of chorionic villi in the placentas of women with CVD. In a study population of 12 pregnant women, 6 with and 6 without CVD, we compared through mass spectroscopy coupled to ultra-high performance liquid chromatography (UHPLC-MS), 240 metabolites in chorionic villus samples. Results: This study is the first to detect in the placental villi of pregnant women with CVD, modifications in lysophosphatidylcholines and amino acids along with diminished levels of other lipids such as triglycerides, sphingomyelins, and non-esterified omega 9 fatty acids, suggesting a role of these abnormalities in the pathogenesis of CVD. Conclusions: Our findings are a starting point for future studies designed to examine the impacts of CVD on maternal and fetal well-being.
PB Ivyspring International Publisher
SN 1449-1907
YR 2020
FD 2020-09-09
LK https://hdl.handle.net/20.500.14352/115201
UL https://hdl.handle.net/20.500.14352/115201
LA eng
NO Ortega MA, Saez MA, Sainz F, Fraile-Martínez O, García-Gallego S, Pekarek L, Bravo C, Coca S, Mon MÁ, Buján J, García-Honduvilla N, Asúnsolo Á. Lipidomic profiling of chorionic villi in the placentas of women with chronic venous disease. Int J Med Sci. 2020 Sep 30;17(17):2790-2798.
NO Instituto de Salud Carlos III
NO European Development Regional Fund
NO B2017/BMD-3804 MITIC-CM.
DS Docta Complutense
RD 18 jul 2025