RT Journal Article
T1 Insights into colloidal nanoparticle-protein corona interactions for nanomedicine applications
A1 Martínez Negro, María
A1 González-Rubio, G
A1 Aicart Sospedra, Emilio
A1 Landfester, K
A1 Guerrero Martínez, Andrés
A1 Junquera González, María Elena
AB Colloidal nanoparticles (NPs) have attracted significant attention due to their unique physicochemical properties suitable for diagnosing and treating different human diseases. Nevertheless, the successful implementation of NPs in medicine demands a proper understanding of their interactions with the different proteins found in biological fluids. Once introduced into the body, NPs are covered by a protein corona (PC) that determines the biological behavior of the NPs. The formation of the PC can eventually favor the rapid clearance of the NPs from the body before fulfilling the desired objective or lead to increased cytotoxicity. The PC nature varies as a function of the different repulsive and attractive forces that govern the NP-protein interaction and their colloidal stability. This review focuses on the phenomenon of PC formation on NPs from a physicochemical perspective, aiming to provide a general overview of this critical process. Main issues related to NP toxicity and clearance from the body as a result of protein adsorption are covered, including the most promising strategies to control PC formation and, thereby, ensure the successful application of NPs in nanomedicine.
PB ELSEVIER
SN 0001-8686
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/108870
UL https://hdl.handle.net/20.500.14352/108870
LA eng
NO Martínez-Negro M, González-Rubio G, Aicart E, Landfester K, Guerrero-Martínez A, Junquera E. Insights into colloidal nanoparticle-protein corona interactions for nanomedicine applications. Advances in Colloid and Interface Science 2021;289:102366. https://doi.org/10.1016/j.cis.2021.102366.
NO Ministerio de Ciencia, Innovación y Universidades
NO Universidad Complutense de Madrid
NO Comunidad de Madrid
NO Deutsche Forschungsgemeinschaft
DS Docta Complutense
RD 6 abr 2025