RT Journal Article
T1 Surface modification, characterization and biofunctionality of pegylated titanate films obtained by the sol-gel method
A1 Hernando Pérez, Mercedes
A1 Muñoz Noval, Álvaro
A1 Rodríguez Navas, Carmen
A1 Manso Silvan, Miguel
A1 Torres-Costa, Vicente
A1 Ceccone, Giacomo
A1 García Ruiz, Josefa P.
A1 Rossi, Francois
AB Pegylated titanates have been prepared as biomedical supports in the form of thin films. The independent preparation of a polyethylene glycol (PEG) and a tetraisopropyl-orthotitanate (TIPT) precursorwas followed by mixing at different molar ratios and spin casting onto Si (100) substrates to form the films. Activation of the hybrid structure was induced by annealing at temperatures right below the PEG melting point. Structural and compositional changes during these steps were followed by Fourier transformed infrared (FTIR) spectroscopy, XPS) and water contact angle (CA) measurements. Biofunctionality of the pegylated titanates as antifouling ophthalmic films was tested on the one hand by determination of optical constants using genetic algorithms. On the other hand, indication of surface biocompatibility was provided by seeding mesenchymal stemcells. The results show that PEG-rich surfaces are less biocompatible than mild inorganic surfaces as derived from the inhibition of cytoskeleton polarization.
PB John Wiley & Sons Ltd
SN 0142-2421
YR 2008
FD 2008-01-04
LK https://hdl.handle.net/20.500.14352/116997
UL https://hdl.handle.net/20.500.14352/116997
LA eng
NO Perez, M. H., Noval, A. M., Navas, C. R., Silvan, M. M., Torres‐Costa, V., Ceccone, G., ... & Rossi, F. (2008). Surface modification, characterization and biofunctionality of pegylated titanate films obtained by the sol‐gel method. Surface and Interface Analysis: An International Journal devoted to the development and application of techniques for the analysis of surfaces, interfaces and thin films, 40(3‐4), 205-209.
DS Docta Complutense
RD 3 abr 2025