RT Journal Article
T1 Frailty Quantified by the “Valencia Score” as a Potential Predictor of Lifespan in Mice
A1 Martínez De Toda Cabeza, Irene
A1 Garrido, Antonio
A1 Vida, Carmen
A1 Gomez-Cabrera, Mari Carmen
A1 Viñas Pinedo, María José
A1 Fuente Del Rey, María Mónica De La
AB The development of frailty scores suitable for mice and which resemble those used in the clinical scenario is of great importance to understand human frailty. The aim of the study was to determine an individual frailty score for each mouse at different ages and analyze the association between the frailty score and its lifespan. For this purpose, the “Valencia Score” for frailty was used. Thus, a longitudinal study in mice was performed analyzing weight loss, running time and speed, grip strength and motor coordination at the late-adult, mature and old ages (40, 56 and 80 weeks old, respectively). These parameters are equivalent to unintentional weight loss, poor endurance, slowness, weakness, and low activity level, respectively, in humans. A cut-off point was used to identify frail mice for each criterion. All the measurements were also performed on chronologically adult prematurely aging mice. The results show that by using the “Valencia Score” for frailty a prematurely aged phenotype can be identified even during the adulthood of animals. This opens up the possibility of carrying out preventive long-term interventions. Moreover, the individual frailty score of a given mouse at the late-adult, mature and old ages is shown to be a relevant predictor of its lifespan.
PB Oxford University Press
SN 1079-5006
YR 2018
FD 2018
LK https://hdl.handle.net/20.500.14352/92298
UL https://hdl.handle.net/20.500.14352/92298
LA eng
NO Irene Martinez de Toda, Antonio Garrido, Carmen Vida, Mari Carmen Gomez-Cabrera, Jose Viña, Monica De la Fuente, Frailty Quantified by the “Valencia Score” as a Potential Predictor of Lifespan in Mice, The Journals of Gerontology: Series A, Volume 73, Issue 10, October 2018, Pages 1323–1329, https://doi.org/10.1093/gerona/gly064
NO Universidad Complutense de Madrid
NO Red Temática de Investigación Cooperativa en Envejecimiento y Fragilidad 
NO European Commission
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 7 abr 2025