RT Journal Article
T1 Fetal development of the human epiglottis revisited: Appearance of GFAP-positive mesenchymal cells and fibrous connections with other laryngeal and lingual structures
A1 Katori, Yukio
A1 Takeuchi, Hiromi
A1 Rodríguez Vázquez, José Francisco
A1 Kitano, Hiroya
A1 Murakami, Gen
A1 Kawase, Tetsuaki
AB The fetal anatomy of the human epiglottis has not yet been fully described. We investigated the histology (paraffin-embedding) of 18 mid-term fetuses at 7-25 weeks of gestation (three fetuses each at 7, 9, 12, 15, 20 and 25 weeks). A mesenchymal condensation of the epiglottic cartilage appears posterior and somewhat superior to the hyoid body at 9 weeks, but at 12 and 15 weeks, the root or inferior part descends to the level of the thyroid cartilage. The covering epithelium stains much darker with hematoxylin than other pharyngeal epithelia. After 20 weeks, the epiglottis again protrudes superiorly beyond the hyoid body. In contrast to other laryngeal cartilage anlagen, the mesenchymal condensation of the epiglottis begins to express glial fibrillary acidic protein (GFAP) at 15 weeks. At the same stage, mucosal glands begin invading into the epiglottic mesenchyme. The developing cartilage becomes penetrated and fragmented by abundant mucosal glands up until 25 weeks. The thyro-epiglottic ligament seems to develop from the GFAP-positive mesenchymal condensation, whereas the hyo-epiglottic ligament is likely to originate from the fasciae of lingual muscles. Epithelial-mesenchymal interaction is strongly suggested in the development of the epiglottic cartilage and concomitant glands.
PB Elsevier
SN 0940-9602
YR 2011
FD 2011-03
LK https://hdl.handle.net/20.500.14352/111957
UL https://hdl.handle.net/20.500.14352/111957
LA eng
NO Katori, Y., Takeuchi, H., Rodríguez-Vázquez, J. F., Kitano, H., Murakami, G., & Kawase, T. (2011). Fetal development of the human epiglottis revisited: Appearance of GFAP-positive mesenchymal cells and fibrous connections with other laryngeal and lingual structures. Annals of Anatomy, 193(2), 149-155. https://doi.org/10.1016/j.aanat.2011.01.003
DS Docta Complutense
RD 19 abr 2025