RT Journal Article
T1 SatR is a repressor of fluoroquinolone efflux pump SatAB
A1 San Millán, Álvaro
A1 Montero Serra, Natalia
A1 Gutiérrez, Belén
A1 Martínez Ovejero, Cristina
A1 Carrilero Aguado, Laura
A1 González Zorn, Bruno
A1 Escudero García-Calderón, José Antonio
AB Streptococcus suis is an emerging zoonotic agent responsible for high-mortality outbreaks among the human population in China. In this species, the ABC transporter SatAB mediates fluoroquinolone resistance when overexpressed. Here, we describe and characterize satR, an open reading frame (ORF) encoding a MarR superfamily regulator that acts as a repressor of satAB. satR is cotranscribed with satAB, and its interruption entails the overexpression of the pump, leading to a clinically relevant increase in resistance to fluoroquinolones.
PB American Society for Microbiology
SN 1098-6596
YR 2013
FD 2013-07
LK https://hdl.handle.net/20.500.14352/35295
UL https://hdl.handle.net/20.500.14352/35295
LA eng
NO Unión Europea. FP7
NO Ministerio de Ciencia e Innovación (MICINN)
NO Comunidad de Madrid
DS Docta Complutense
RD 29 abr 2024